Capsaicin Clinical Studies
Sinol – Clinical Trial   >> click here to read full report.
A solution of capsaicin, SINOL, registered as a homeopathic product in the US , is intended to relieve symptoms of allergic rhinitis (AR) but is untested in controlled experiments. We aimed to document symptom relief by SINOL and to evaluate other potential effects using a capsaicin solution formulated with mucoadhesive technology (SINOL-M), known to prolong adherence with the mucosa.
"This study represents the first-ever capsaicin-based treatment for allergic rhinitis to be supported by prospective clinical data, and has important implications for millions of Americans who suffer from nasal allergies. This all-natural product has now been demonstrated to provide clinical effectiveness without any of the side effects associated with intra-nasal steroids and is available without a prescription"
Dr. Michael A. Kaliner, of the Institute of Asthma and Allergy, Wheaton, Maryland, and principal author and presenter of this poster.

Medline – Clinical Trial
Capsaicin is effective Natural Allergy Remedy for psoriasis, pruritus, and cluster headaches.
Department of Anesthesia and Critical Care, the University of Chicago, Illinois

Intranasal Capsaicin Reduces Allergic Symptoms
Patients who were challenged with natural capsaicin reported a long lasting relief of symptoms that included rhinnorhea, congestion, sneezing and coughing (this relief was reported to have lasted up to 9 months after treatment).
Johns Hopkins Bayview Medical Center

Medline – Clinical Trial
It has been suggested that treatment of cluster headache (CH) patients with topical capsaicin may desensitize sensory neurons by depleting the nerve terminals of substance P. We attempted to determine whether capsaicin is effective in aborting CH attacks. Patients in acute cluster were randomized to receive either capsaicin or placebo in the ipsilateral nostril for 7 days. Patients recorded the severity of each headache for 15 days. Headaches on days 8-15 of the study were significantly less severe in the capsaicin group vs the placebo group. There was also a significant decrease in headache severity in the capsaicin group on days 8-15 compared to days 1-7, but not in the placebo group. Episodic CH patients appeared to benefit more than chronic CH patients. These results indicate that intranasal capsaicin may provide a new therapeutic option for the treatment of this disease.
Clinical Immunology Unit, Massachusetts General Hospital, Boston 92114.

Medline – Clinical Trial
Intranasal medications for the treatment of headaches is significantly more effective than by digestive means.
Columbia University College of Physicians & Surgeons, New York, NY

Medline – Clinical Trial
Intranasal Civamide (capsaicin) solution at a dose of 50 microg may be modestly effective in the preventive treatment of episodic cluster headache.
Michigan Headache Pain and Neurological Institute

Medline – Clinical Trial
Based upon the results of this study, intranasal civamide may be effective in the acute treatment of migraine headache.
Diamond Headache Clinic, Chicago, IL

Medline – Clinical Trial
Finally, repeated applications of the drug to the nasal mucosa result in the prevention of cluster headache attacks. On the basis of this evidence, capsaicin appears to be a promising prototype for obtaining selective analgesia in localised pain syndromes.
Department of Clinical Medicine, University La Sapienza, Rome, Italy

Medscape
A 2002 report in the Archives of Neurology reported the use of natual capsaicin nasal spray to treat cluster and migraine headaches.[11] Capsaicin depletes substance P and may represent a new treatment for this painful condition.
Robert Baldor, MD University of Massachusetts Medical School

The Wall Street Journal – Pepper Unclogs Sinuses
“Since capsaicin desensitizes the mucous membranes in the nose, it make them less irritated by airborne particles helping to relieve congestion. We pepper our patients regularly using a solution of saline, ethanol and capsaicin.”
J.S. LaCroix – Research Scientist University Hospital, Geneva

Warning: Not recommended for children under 12. If you are pregnant or nursing, ask a healthcare professional before use.


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